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Chemical structure of Larotinib

GC73414

Larotinib

Also known as 6-[3-[(4aS,7aR)-2,3,4a,5,7,7a-hexahydro-[1,4]dioxino[2,3-c]pyrrol-6-yl]propoxy]-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine

Larotinib is a potent broad-spectrum and orally active tyrosine kinase inhibitor (TKI) with EGFR as the main target with an IC50 of 0·6 nM

ChemicalCAS1438072-11-7MW488.94FormulaC24H26ClFN4O4
CAS number
1438072-11-7
Molecular weight
488.94
Formula
C24H26ClFN4O4
Solubility
DMSO ： 125 mg/mL (255·66 mM; Need ultrasonic)
InChIKey
UFUKZMIXTOMMLU-ZRZAMGCNSA-N
Catalogue number
GC73414
Brand
GLPBIO
Computed properties PubChem CID 89584422 · XLogP 3.9 · TPSA 78 Ų · H-bond donors 1
XLogP
3.9
TPSA
78 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
8
Heavy atoms
34

SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4C[C@@H]5[C@H](C4)OCCO5

Computed descriptors from PubChem (CID 89584422), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
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