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Chemical structure of Menin-MLL inhibitor-22

GC73357

Menin-MLL inhibitor-22

Also known as N-[1-[[1-(4-cyclopropylsulfonylphenyl)azetidin-3-yl]methyl]piperidin-4-yl]-6-[2-(dimethylamino)ethoxy]pyrido[3,2-d]pyrimidin-4-amine

Menin-MLL inhibitor-22 (compound C20) is an orally active inhibitor of the interaction between menin and mixed lineage leukemia (MLL) (IC50=7 nM)

ChemicalCAS2851841-61-5MW565.73FormulaC29H39N7O3S
CAS number
2851841-61-5
Molecular weight
565.73
Formula
C29H39N7O3S
Solubility
DMSO ： 125 mg/mL (220·95 mM; Need ultrasonic)
InChIKey
MWXGAMJNJKYTPA-UHFFFAOYSA-N
Catalogue number
GC73357
Brand
GLPBIO
Computed properties PubChem CID 168286999 · XLogP 3.5 · TPSA 112 Ų · H-bond donors 1
XLogP
3.5
TPSA
112 Ų
H-bond donors
1
H-bond acceptors
10
Rotatable bonds
11
Heavy atoms
40

SMILES CN(C)CCOC1=NC2=C(C=C1)N=CN=C2NC3CCN(CC3)CC4CN(C4)C5=CC=C(C=C5)S(=O)(=O)C6CC6

Computed descriptors from PubChem (CID 168286999), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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