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Chemical structure of THRX-144644

GC73292

THRX-144644

Also known as 6-[5-(5-chloro-2,4-difluorophenyl)-1H-pyrazol-4-yl]-N-[2-(4-propan-2-ylpiperazin-1-yl)ethyl]-1,5-naphthyridin-3-amine

THRX-144644 is a Lung-restricted ALK5 inhibitor with an IC50 value of 0·14 nM

ChemicalCAS2442519-59-5MW512FormulaC26H28ClF2N7
CAS number
2442519-59-5
Molecular weight
512
Formula
C26H28ClF2N7
Solubility
DMSO ： 50 mg/mL (97·66 mM; Need ultrasonic)
InChIKey
ATWFNMAJIPYWCA-UHFFFAOYSA-N
Catalogue number
GC73292
Brand
GLPBIO
Computed properties PubChem CID 146661749 · XLogP 4.3 · TPSA 73 Ų · H-bond donors 2
XLogP
4.3
TPSA
73 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
36

SMILES CC(C)N1CCN(CC1)CCNC2=CC3=C(C=CC(=N3)C4=C(NN=C4)C5=CC(=C(C=C5F)F)Cl)N=C2

Computed descriptors from PubChem (CID 146661749), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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