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Chemical structure of BWA-522

GC73237

BWA-522

Also known as 5-[4-[[4-[[4-[2-[4-[(2S)-3-chloro-2-hydroxypropoxy]phenyl]propan-2-yl]phenoxy]methyl]piperidin-1-yl]methyl]piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

BWA-522 is an orally available small molecule protein-targeting chimera (PROTACs) with significant degradation effect on AR-FL and AR-V7

ChemicalCAS3042820-12-9MW771.34FormulaC43H51ClN4O7
CAS number
3042820-12-9
Molecular weight
771.34
Formula
C43H51ClN4O7
Solubility
DMSO : 90 mg/mL (116·68 mM; Need ultrasonic)
InChIKey
MYCPBYLZNZTLBC-OVFDOZPJSA-N
Catalogue number
GC73237
Brand
GLPBIO
Computed properties PubChem CID 168679672 · XLogP 6.2 · TPSA 129 Ų · H-bond donors 2
XLogP
6.2
TPSA
129 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
13
Heavy atoms
55

SMILES CC(C)(C1=CC=C(C=C1)OCC2CCN(CC2)CC3CCN(CC3)C4=CC5=C(C=C4)C(=O)N(C5=O)C6CCC(=O)NC6=O)C7=CC=C(C=C7)OC[C@@H](CCl)O

Computed descriptors from PubChem (CID 168679672), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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