Loading...
Chemical structure of SP27

GC73230

SP27

Also known as 5-[4-[4-[6-[(2,4-difluorophenyl)methylamino]-4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

SP27 is a PROTAC that can selective degrades PLK4, with a DC50 of 19·5 nM

ChemicalCAS3034805-75-6MW806.82FormulaC40H40F2N12O5
CAS number
3034805-75-6
Molecular weight
806.82
Formula
C40H40F2N12O5
Solubility
DMSO ： 100 mg/mL (123·94 mM; Need ultrasonic)
InChIKey
NTSTTXFDEIQUET-UHFFFAOYSA-N
Catalogue number
GC73230
Brand
GLPBIO
Computed properties PubChem CID 170903490 · XLogP 3.5 · TPSA 203 Ų · H-bond donors 4
XLogP
3.5
TPSA
203 Ų
H-bond donors
4
H-bond acceptors
14
Rotatable bonds
9
Heavy atoms
59

SMILES CC1=CC(=NN1)NC2=C3C=NN(C3=NC(=N2)NCC4=C(C=C(C=C4)F)F)C5CCN(CC5)C(=O)C6CCN(CC6)C7=CC8=C(C=C7)C(=O)N(C8=O)C9CCC(=O)NC9=O

Computed descriptors from PubChem (CID 170903490), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.