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Chemical structure of CK156

GC73211

CK156

Also known as N-tert-butyl-7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxamide

CK156 is a highly selective death-associated protein kinase (DAPK) inhibitor with IC50s of 182 nM,34 μM, and 39 μM in the DRAK1 NanoBRET assay for DRAK1, CK2a1, and CK2a2, respectively

ChemicalCAS2910938-59-7MW395.45FormulaC21H25N5O3
CAS number
2910938-59-7
Molecular weight
395.45
Formula
C21H25N5O3
Solubility
DMSO : 100 mg/mL (252·88 mM; Need ultrasonic)
InChIKey
YCFFONJEHNSECY-UHFFFAOYSA-N
Catalogue number
GC73211
Brand
GLPBIO
Computed properties PubChem CID 162623416 · XLogP 2.1 · TPSA 89.8 Ų · H-bond donors 2
XLogP
2.1
TPSA
89.8 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
2
Heavy atoms
29

SMILES CC(C)(C)NC(=O)C1=C2C=C(C=C1)C3=C4N=C(C=CN4N=C3)NCCOCCO2

Computed descriptors from PubChem (CID 162623416), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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