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Chemical structure of HRO761

GC73193

HRO761

Also known as N-[2-chloro-4-(trifluoromethyl)phenyl]-2-[2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-(5-hydroxy-6-methylpyrimidine-4-carbonyl)piperazin-1-yl]-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]acetamide

HRO761 (Werner syndrome RecQ helicase-IN-1) (example 42) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research

ChemicalCAS2869954-34-5MW702.08FormulaC31H31ClF3N9O5
CAS number
2869954-34-5
Molecular weight
702.08
Formula
C31H31ClF3N9O5
Solubility
DMSO ： 100 mg/mL (142·43 mM; Need ultrasonic)
InChIKey
XKYVECRUZPCRQR-UHFFFAOYSA-N
Catalogue number
GC73193
Brand
GLPBIO
Computed properties PubChem CID 166140536 · XLogP 4 · TPSA 159 Ų · H-bond donors 2
XLogP
4
TPSA
159 Ų
H-bond donors
2
H-bond acceptors
14
Rotatable bonds
7
Heavy atoms
49

SMILES CCC1=C(C(=O)N2C(=NC(=N2)C3=CCOCC3)N1CC(=O)NC4=C(C=C(C=C4)C(F)(F)F)Cl)N5CCN(CC5)C(=O)C6=NC=NC(=C6O)C

Computed descriptors from PubChem (CID 166140536), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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