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Chemical structure of HQ005

GC73181

HQ005

Also known as 2-[2-[[6-(hydroxymethyl)-2-pyridinyl]amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide

HQ005 is a potent CCNK degrader with an DC50 value of 0·041 µM

ChemicalCAS2750644-31-4MW361.44FormulaC15H15N5O2S2
CAS number
2750644-31-4
Molecular weight
361.44
Formula
C15H15N5O2S2
InChIKey
RCCDIUZAPKBQLV-UHFFFAOYSA-N
Catalogue number
GC73181
Brand
GLPBIO
Computed properties PubChem CID 165665550 · XLogP 1.8 · TPSA 157 Ų · H-bond donors 3
XLogP
1.8
TPSA
157 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
24

SMILES CC1=CN=C(S1)NC(=O)CC2=CSC(=N2)NC3=CC=CC(=N3)CO

Computed descriptors from PubChem (CID 165665550), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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