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Chemical structure of HaloPROTAC-E

GC73111

HaloPROTAC-E

Also known as (2S,4R)-N-[[2-[2-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide

HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM

ChemicalCAS2365478-58-4MW790.41FormulaC39H56ClN5O8S
CAS number
2365478-58-4
Molecular weight
790.41
Formula
C39H56ClN5O8S
Solubility
DMSO ： 100 mg/mL (126·52 mM; Need ultrasonic)
InChIKey
NJCGXLMTZGCSRS-JSWXEYCZSA-N
Catalogue number
GC73111
Brand
GLPBIO
Computed properties PubChem CID 154723985 · XLogP 4.1 · TPSA 201 Ų · H-bond donors 3
XLogP
4.1
TPSA
201 Ų
H-bond donors
3
H-bond acceptors
11
Rotatable bonds
24
Heavy atoms
54

SMILES CC1=C(SC=N1)C2=CC(=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)C4(CC4)C#N)O)OCCOCCOCCOCCCCCCCl

Computed descriptors from PubChem (CID 154723985), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.