Loading...
Chemical structure of AEP-IN-3

GC71489

AEP-IN-3

Also known as (2S,4R)-N-[(3S)-5-amino-5-oxopent-1-yn-3-yl]-4-fluoro-1-[1-[4-(trifluoromethoxy)phenyl]cyclopropanecarbonyl]pyrrolidine-2-carboxamide

AEP-IN-3 (compound 18) is an orally active, potent and brain penetrant asparagine endopeptidase (AEP) inhibitor, with an IC50 of 7·8 ± 0·9 nM

ChemicalCAS2978521-26-3MW455.4FormulaC21H21F4N3O4
CAS number
2978521-26-3
Molecular weight
455.4
Formula
C21H21F4N3O4
Solubility
DMSO ： 100 mg/mL (219·59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
WXTJCPHELGTTJU-FMKPAKJESA-N
Catalogue number
GC71489
Brand
GLPBIO
Computed properties PubChem CID 169171740 · XLogP 1.8 · TPSA 102 Ų · H-bond donors 2
XLogP
1.8
TPSA
102 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
32

SMILES C#C[C@H](CC(=O)N)NC(=O)[C@@H]1C[C@H](CN1C(=O)C2(CC2)C3=CC=C(C=C3)OC(F)(F)F)F

Computed descriptors from PubChem (CID 169171740), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.