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Chemical structure of HJM-561

GC71400

HJM-561

Also known as 3-[7-[4-[4-[1-[4-[[5-chloro-4-(2-dimethylphosphorylanilino)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperidin-4-yl]piperazin-1-yl]but-1-ynyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione

HJM-561 is a potent, selective, orally bioavailable EGFR PROTAC

ChemicalCAS2570251-68-0MW864.37FormulaC45H51ClN9O5P
CAS number
2570251-68-0
Molecular weight
864.37
Formula
C45H51ClN9O5P
Solubility
DMSO ： 100 mg/mL (115·69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
WTUTUUAYVNLJQA-UHFFFAOYSA-N
Catalogue number
GC71400
Brand
GLPBIO
Computed properties PubChem CID 155680191 · XLogP 5.3 · TPSA 152 Ų · H-bond donors 3
XLogP
5.3
TPSA
152 Ų
H-bond donors
3
H-bond acceptors
12
Rotatable bonds
12
Heavy atoms
61

SMILES COC1=C(C=CC(=C1)N2CCC(CC2)N3CCN(CC3)CCC#CC4=C5CN(C(=O)C5=CC=C4)C6CCC(=O)NC6=O)NC7=NC=C(C(=N7)NC8=CC=CC=C8P(=O)(C)C)Cl

Computed descriptors from PubChem (CID 155680191), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.