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Chemical structure of LY1

GC71194

LY1

Also known as 2,2-dioxo-5-(2-piperazin-1-ylanilino)-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),3,5,8(12),9-pentaen-7-one;hydrochloride

LY1 is a potent, selective and covalent inhibitor against both SARS-CoV-2 PLpro and Mpro with Kd values of 1·5 μM and 2·3 μM for Mpro C145A protein and PLpro C111A protein, respectively

ChemicalCAS2883813-32-7MW430.91FormulaC20H19ClN4O3S
CAS number
2883813-32-7
Molecular weight
430.91
Formula
C20H19ClN4O3S
Solubility
DMSO ： 50 mg/mL (116·03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
RVXKOLGQSWIVHC-UHFFFAOYSA-N
Catalogue number
GC71194
Brand
GLPBIO
Computed properties PubChem CID 166642379 · TPSA 99.3 Ų · H-bond donors 3 · H-bond acceptors 7
TPSA
99.3 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
3
Heavy atoms
29

SMILES C1CN(CCN1)C2=CC=CC=C2NC3=CC(=O)C4=C5C3=NS(=O)(=O)C5=CC=C4.Cl

Computed descriptors from PubChem (CID 166642379), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.