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Chemical structure of Suzetrigine

GC71054

Suzetrigine

Also known as 4-[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-carbonyl]amino]pyridine-2-carboxamide

Suzetrigine (VX-548) is an orally active and highly selective NaV1·8 inhibitor that acts as an analgesic

ChemicalCAS2649467-58-1MW473.39FormulaC21H20F5N3O4
CAS number
2649467-58-1
Molecular weight
473.39
Formula
C21H20F5N3O4
Solubility
DMSO ： 125 mg/mL (264·05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
XSQUJFKRXZMOKA-PAFIKIDNSA-N
Catalogue number
GC71054
Brand
GLPBIO
Computed properties PubChem CID 156445116 · XLogP 3 · TPSA 104 Ų · H-bond donors 2
XLogP
3
TPSA
104 Ų
H-bond donors
2
H-bond acceptors
10
Rotatable bonds
5
Heavy atoms
33

SMILES C[C@H]1[C@H]([C@@H](O[C@@]1(C)C(F)(F)F)C(=O)NC2=CC(=NC=C2)C(=O)N)C3=C(C(=C(C=C3)F)F)OC

Computed descriptors from PubChem (CID 156445116), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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