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Chemical structure of GLP-1R agonist 12

GC71004

GLP-1R agonist 12

Also known as 2-[[4-[6-[(2-cyclopropylpyrazolo[1,5-a]pyridin-6-yl)methoxy]-2-pyridinyl]piperidin-1-yl]methyl]-3-[[(2S)-oxetan-2-yl]methyl]benzimidazole-5-carboxylic acid

GLP-1R agonist 12 (Compound 123) is an agonist of glucagon-like peptide-1 receptors (GLP-1R)

ChemicalCAS2765595-19-3MW592.69FormulaC34H36N6O4
CAS number
2765595-19-3
Molecular weight
592.69
Formula
C34H36N6O4
Solubility
DMSO : 100 mg/mL (168·72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
TUSYJBRBOOOKPJ-MHZLTWQESA-N
Catalogue number
GC71004
Brand
GLPBIO
Computed properties PubChem CID 163230614 · XLogP 1.3 · TPSA 107 Ų · H-bond donors 1
XLogP
1.3
TPSA
107 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
10
Heavy atoms
44

SMILES C1CO[C@@H]1CN2C3=C(C=CC(=C3)C(=O)O)N=C2CN4CCC(CC4)C5=NC(=CC=C5)OCC6=CN7C(=CC(=N7)C8CC8)C=C6

Computed descriptors from PubChem (CID 163230614), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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