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Chemical structure of DFBTA

GC70963

DFBTA

Also known as 4-(4-chlorophenyl)-2-[(2,5-difluorobenzoyl)amino]thiophene-3-carboxylic acid

DFBTA is an orally active, potent and little brain penetrated ANO1 (Calcium-activated chloride channel anoctamin-1) inhibitor, with an IC50 of 24 nM

ChemicalCAS2966044-07-3MW393.79FormulaC18H10ClF2NO3S
CAS number
2966044-07-3
Molecular weight
393.79
Formula
C18H10ClF2NO3S
Solubility
DMSO ： 100 mg/mL (253·94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
RZXHOVMOLRFUCA-UHFFFAOYSA-N
Catalogue number
GC70963
Brand
GLPBIO
Computed properties PubChem CID 163409120 · XLogP 5.3 · TPSA 94.6 Ų · H-bond donors 2
XLogP
5.3
TPSA
94.6 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
26

SMILES C1=CC(=CC=C1C2=CSC(=C2C(=O)O)NC(=O)C3=C(C=CC(=C3)F)F)Cl

Computed descriptors from PubChem (CID 163409120), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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