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Chemical structure of (R)-Vanzacaftor

GC70934

(R)-Vanzacaftor

Also known as (14R)-8-[3-(2-dispiro[2.0.24.13]heptan-7-ylethoxy)pyrazol-1-yl]-12,12-dimethyl-2,2-dioxo-2lambda6-thia-3,9,11,18,23-pentazatetracyclo[17.3.1.111,14.05,10]tetracosa-1(22),5(10),6,8,19(23),20-hexaen-4-one

(R)-Vanzacaftor ((R)-VX-121) is a regulator of cystic fibrosis transmembrane conduction regulator (CFTR)

ChemicalCAS2374124-48-6MW617.76FormulaC32H39N7O4S
CAS number
2374124-48-6
Molecular weight
617.76
Formula
C32H39N7O4S
Solubility
DMSO ： 100 mg/mL (161·88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
VCSUIBJKYCVWNF-OAQYLSRUSA-N
Catalogue number
GC70934
Brand
GLPBIO
Computed properties PubChem CID 139400306 · XLogP 5.7 · TPSA 140 Ų · H-bond donors 2
XLogP
5.7
TPSA
140 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
5
Heavy atoms
44

SMILES CC1(C[C@H]2CCCNC3=NC(=CC=C3)S(=O)(=O)NC(=O)C4=C(N1C2)N=C(C=C4)N5C=CC(=N5)OCCC6C7(C68CC8)CC7)C

Computed descriptors from PubChem (CID 139400306), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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