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Chemical structure of TLR7/8 antagonist 2

GC70900

TLR7/8 antagonist 2

Also known as 5-cyclopropyl-6-(2,6-dimethyl-4-pyridinyl)-N-[(3S,4S)-3-fluoropiperidin-4-yl]-1H-indazol-3-amine

TLR7/8 antagonist 2 (Compound 15) is a potent and orally active agonist of TLR7/8 with IC50s of 4·9 and 0·6 nM, respectively

ChemicalCAS2769085-03-0MW379.47FormulaC22H26FN5
CAS number
2769085-03-0
Molecular weight
379.47
Formula
C22H26FN5
Solubility
DMSO ： 100 mg/mL (263·53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
JUSJRQVEHUHMRQ-PMACEKPBSA-N
Catalogue number
GC70900
Brand
GLPBIO
Computed properties PubChem CID 163196406 · XLogP 4.3 · TPSA 65.6 Ų · H-bond donors 3
XLogP
4.3
TPSA
65.6 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
28

SMILES CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2)NN=C3N[C@H]4CCNC[C@@H]4F)C5CC5

Computed descriptors from PubChem (CID 163196406), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.