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Chemical structure of QO-40

GC70632

QO-40

Also known as 5-(chloromethyl)-3-naphthalen-1-yl-2-(trifluoromethyl)-1H-pyrazolo[1,5-a]pyrimidin-7-one

QO-40 is a pyrazolo[1,5-a]pyrimidine-7(4H)-one (PPO) derivative and an activator of the voltage-gated M-type potassium channel KCNQ encoded by the KCNQ2/3 gene (EC50: 1·25 μM)

ChemicalCAS1259536-70-3MW377.75FormulaC18H11ClF3N3O
CAS number
1259536-70-3
Molecular weight
377.75
Formula
C18H11ClF3N3O
InChIKey
PAIKWVVGBGIKJH-UHFFFAOYSA-N
Catalogue number
GC70632
Brand
GLPBIO
Computed properties PubChem CID 51356808 · XLogP 3.8 · TPSA 44.7 Ų · H-bond donors 1
XLogP
3.8
TPSA
44.7 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
2
Heavy atoms
26

SMILES C1=CC=C2C(=C1)C=CC=C2C3=C(NN4C3=NC(=CC4=O)CCl)C(F)(F)F

Computed descriptors from PubChem (CID 51356808), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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