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Chemical structure of UMK57

GC70529

UMK57

Also known as 5-(4-methylphenyl)-4-pyrrolidin-1-ylthieno[2,3-d]pyrimidine

UMK57 is a small molecule compound that specifically promotes k-MT attachment error correction to inhibit chromosome missegregation, which can improve chromosome segregation fidelity by destabilizing kinetochore microtubule (k-MT) attachment during mitosis

ChemicalCAS342595-74-8MW295.4FormulaC17H17N3S
CAS number
342595-74-8
Molecular weight
295.4
Formula
C17H17N3S
Solubility
Ethanol ： 6·67 mg/mL (22·58 mM; Need ultrasonic)DMSO ： 2 mg/mL (6·77 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
VOAWQTDHSSKEKA-UHFFFAOYSA-N
Catalogue number
GC70529
Brand
GLPBIO
Computed properties PubChem CID 693939 · XLogP 4.5 · TPSA 57.3 Ų · H-bond donors 0
XLogP
4.5
TPSA
57.3 Ų
H-bond donors
0
H-bond acceptors
4
Rotatable bonds
2
Heavy atoms
21

SMILES CC1=CC=C(C=C1)C2=CSC3=NC=NC(=C23)N4CCCC4

Computed descriptors from PubChem (CID 693939), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.