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Chemical structure of WM382

GC70146

WM382

Also known as (4R)-4-(2-amino-4,4-diethyl-6-oxo-5H-pyrimidin-1-yl)-N-[(4S)-2,2-dimethyl-3,4-dihydrochromen-4-yl]-3,4-dihydro-2H-chromene-6-carboxamide

WM382 is an orally effective dual plasma proteinase inhibitor of factor IX/X (PMIX/X), with IC50 values of 1·4 nM and 0·03 nM, respectively· WM382 has good in vivo efficacy and resistance to multiple stages of the malaria parasite life cycle

ChemicalCAS2606990-92-3MW504.62FormulaC29H36N4O4
CAS number
2606990-92-3
Molecular weight
504.62
Formula
C29H36N4O4
Solubility
DMSO ： 5 mg/mL (9·91 mM; ultrasonic and warming and heat to 60°C)
InChIKey
ZSZSSSHEMYULPX-FCHUYYIVSA-N
Catalogue number
GC70146
Brand
GLPBIO
Computed properties PubChem CID 154699453 · XLogP 3.4 · TPSA 106 Ų · H-bond donors 2
XLogP
3.4
TPSA
106 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
37

SMILES CCC1(CC(=O)N(C(=N1)N)[C@@H]2CCOC3=C2C=C(C=C3)C(=O)N[C@H]4CC(OC5=CC=CC=C45)(C)C)CC

Computed descriptors from PubChem (CID 154699453), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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