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Chemical structure of Vamotinib

GC70110

Vamotinib

Also known as 4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)ethynyl]benzamide

Vamotinib (PF-114) is an effective, selective and orally active tyrosine kinase inhibitor· Vamotinib inhibits the self-phosphorylation of BCR/ABL and BCR/ABL-T315I· Vamotinib induces apoptosis· Vamotinib exhibits anti-proliferative and anti-tumor activity· Vamotinib has potential in the study of resistant Philadelphia chromosome-positive (Ph+) leukemia

ChemicalCAS1416241-23-0MW532.56FormulaC29H27F3N6O
CAS number
1416241-23-0
Molecular weight
532.56
Formula
C29H27F3N6O
Solubility
DMSO ： 50 mg/mL (93·89 mM; Need ultrasonic)
InChIKey
SLIVDYMORZGPLW-UHFFFAOYSA-N
Catalogue number
GC70110
Brand
GLPBIO
Computed properties PubChem CID 71475839 · XLogP 5 · TPSA 65.8 Ų · H-bond donors 1
XLogP
5
TPSA
65.8 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
39

SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=NN=C5N4C=CC=C5

Computed descriptors from PubChem (CID 71475839), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.