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Chemical structure of USP30 inhibitor 11

GC70099

USP30 inhibitor 11

Also known as (2S)-1-cyano-N-[4-(6-cyano-5-methoxy-2-pyridinyl)-1,3-thiazol-2-yl]-N-methylpyrrolidine-2-carboxamide

USP30 inhibitor 11 is a selective and effective inhibitor of USP30, with an IC50 value of 0·01 µμ· It is Example 83 derived from patent document WO2017009650A1, used for research on cancer and diseases involving mitochondrial dysfunction

ChemicalCAS2067332-64-1MW368.41FormulaC17H16N6O2S
CAS number
2067332-64-1
Molecular weight
368.41
Formula
C17H16N6O2S
InChIKey
APFKLZAHDDDAOH-AWEZNQCLSA-N
Catalogue number
GC70099
Brand
GLPBIO
Computed properties PubChem CID 124197552 · XLogP 2.2 · TPSA 134 Ų · H-bond donors 0
XLogP
2.2
TPSA
134 Ų
H-bond donors
0
H-bond acceptors
8
Rotatable bonds
4
Heavy atoms
26

SMILES CN(C1=NC(=CS1)C2=NC(=C(C=C2)OC)C#N)C(=O)[C@@H]3CCCN3C#N

Computed descriptors from PubChem (CID 124197552), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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