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Chemical structure of UNC9995

GC70092

UNC9995

Also known as 5-[3-[4-(2,3-dichlorophenyl)piperazin-1-yl]propoxy]-1,3-benzothiazole

UNC9995 is an agonist of the dopamine receptor Drd2· UNC9995 inhibits NLRP3 inflammasome activation by enhancing β-arrestin2-NLRP3 interaction, thereby preventing neuronal degeneration· In addition, UNC9995 activates Drd2/β-arrestin2 signaling to block inflammation-related gene transcription induced by JAK/STAT3· UNC9995 also improves depressive behavior in mouse models and ameliorates astrocyte dysfunction

ChemicalCAS1354030-52-6MW422.37FormulaC20H21Cl2N3OS
CAS number
1354030-52-6
Molecular weight
422.37
Formula
C20H21Cl2N3OS
Solubility
DMSO ： 50 mg/mL (118·38 mM; ultrasonic and warming and heat to 60°C)
InChIKey
VBHBKXBUHHJVBZ-UHFFFAOYSA-N
Catalogue number
GC70092
Brand
GLPBIO
Computed properties PubChem CID 56599143 · XLogP 5.6 · TPSA 56.8 Ų · H-bond donors 0
XLogP
5.6
TPSA
56.8 Ų
H-bond donors
0
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
27

SMILES C1CN(CCN1CCCOC2=CC3=C(C=C2)SC=N3)C4=C(C(=CC=C4)Cl)Cl

Computed descriptors from PubChem (CID 56599143), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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