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Chemical structure of Trametiglue

GC70053

Trametiglue

Also known as 3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-1-[3-(methylsulfamoylamino)phenyl]pyrido[4,3-d]pyrimidine-2,4,7-trione

Trametiglue is a derivative of Trametinib that binds to KSR-MEK and RAF-MEK with unprecedented potency and selectivity through a unique interface interaction

ChemicalCAS2666940-97-0MW666.46FormulaC25H24FIN6O5S
CAS number
2666940-97-0
Molecular weight
666.46
Formula
C25H24FIN6O5S
Solubility
DMSO ： 100 mg/mL (150·05 mM; ultrasonic and warming and heat to 60°C)
InChIKey
DNNMBAWCLGMMRJ-UHFFFAOYSA-N
Catalogue number
GC70053
Brand
GLPBIO
Computed properties PubChem CID 154700547 · XLogP 2.9 · TPSA 140 Ų · H-bond donors 3
XLogP
2.9
TPSA
140 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
7
Heavy atoms
39

SMILES CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NS(=O)(=O)NC)C5CC5

Computed descriptors from PubChem (CID 154700547), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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