GC70046
TP0427736 hydrochloride
Also known as 6-[5-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-4-yl]-1,3-benzothiazole;hydrochloride
TP0427736 hydrochloride is an effective inhibitor of ALK5 kinase activity, with an IC50 of 2·72 nM· This action is 300 times higher than its inhibitory effect on ALK3 (IC50 for inhibiting ALK3 is 836 nM)· TP0427736 hydrochloride also inhibits the phosphorylation of Smad2/3 induced by TGF-β1 in A549 cells, with an IC50 value of 8·68 nM
ChemicalCAS2459963-17-6MW334.85FormulaC14H11ClN4S2
- CAS number
- 2459963-17-6
- Molecular weight
- 334.85
- Formula
- C14H11ClN4S2
- InChIKey
- DBKPLYNIVZJPCU-UHFFFAOYSA-N
- Catalogue number
- GC70046
- Brand
- GLPBIO
Computed properties PubChem CID 137277519 · TPSA 111 Ų · H-bond donors 2 · H-bond acceptors 5
- TPSA
- 111 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Rotatable bonds
- 2
- Heavy atoms
- 21
SMILES CC1=CSC(=N1)C2=C(N=CN2)C3=CC4=C(C=C3)N=CS4.Cl
Computed descriptors from PubChem (CID 137277519), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il