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Chemical structure of TIE-2/VEGFR-2 kinase-IN-2

GC70028

TIE-2/VEGFR-2 kinase-IN-2

Also known as 1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea

TIE-2/VEGFR-2 kinase-IN-2 is an effective dual inhibitor of VEGFR2 and Tie-2, with pIC50 values of 8·61 and 8·56 respectively· TIE-2/VEGFR-2 kinase-IN-2 is an antiangiogenic agent that can be used in cancer research

ChemicalCAS501693-48-7MW431.34FormulaC20H13F4N5O2
CAS number
501693-48-7
Molecular weight
431.34
Formula
C20H13F4N5O2
InChIKey
KNDPXYAMINMLED-UHFFFAOYSA-N
Catalogue number
GC70028
Brand
GLPBIO
Computed properties PubChem CID 10113568 · XLogP 3.8 · TPSA 106 Ų · H-bond donors 3
XLogP
3.8
TPSA
106 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
3
Heavy atoms
31

SMILES C1=CC(=CC=C1C2=COC3=NC=NC(=C23)N)NC(=O)NC4=C(C=CC(=C4)C(F)(F)F)F

Computed descriptors from PubChem (CID 10113568), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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