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Chemical structure of STAT3-IN-11

GC69952

STAT3-IN-11

Also known as N-[2-(8-hydroxy-3-methyl-1,4-dioxonaphthalen-2-yl)ethyl]benzamide

STAT3-IN-11 (7a) is a selective inhibitor of STAT3 that can inhibit the phosphorylation of the pTyr705 site on STAT3· It can also inhibit downstream genes (Survivin and Mcl-1) without affecting upstream tyrosine kinases (Src and JAK2) and p-STAT1 expression· STAT3-IN-11 can induce apoptosis in cancer cells, making it a promising candidate for the discovery of STAT3 inhibitors and anti-tumor agents

ChemicalCAS2503096-50-0MW335.35FormulaC20H17NO4
CAS number
2503096-50-0
Molecular weight
335.35
Formula
C20H17NO4
Solubility
DMSO ： 100 mg/mL (298·20 mM; Need ultrasonic)
InChIKey
XLSYRTJOLUDGSR-UHFFFAOYSA-N
Catalogue number
GC69952
Brand
GLPBIO
Computed properties PubChem CID 164517204 · XLogP 3.3 · TPSA 83.5 Ų · H-bond donors 2
XLogP
3.3
TPSA
83.5 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
25

SMILES CC1=C(C(=O)C2=C(C1=O)C=CC=C2O)CCNC(=O)C3=CC=CC=C3

Computed descriptors from PubChem (CID 164517204), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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