GC69940
SR 142948 dihydrochloride
SR 142948 dihydrochloride is an orally active and selective non-peptide antagonist of the neurotensin receptor (NT)· Its IC50 values are 1·19 nM, 0·32 nM, and 3·96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain respectively· SR 142948 dihydrochloride inhibits NT-induced inositol phosphate formation with an IC50 value of 3·9 nM in HT-29 cells· In vivo, it blocks NT-induced hypothermia, analgesia, and turning behavior· SR 142948 dihydrochloride can penetrate the blood-brain barrier and can be used for research on psychiatric disorders
ChemicalMW758.77FormulaC39H53Cl2N5O6
- CAS number
- —
- Molecular weight
- 758.77
- Formula
- C39H53Cl2N5O6
- Solubility
- H2O ： 50 mg/mL (65·90 mM; Need ultrasonic); DMSO ： 10 mg/mL (13·18 mM; Need ultrasonic)
- Catalogue number
- GC69940
- Brand
- GLPBIO
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il