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Chemical structure of SPH3127

GC69938

SPH3127

Also known as methyl N-[3-[3-[(1R)-1-[cyclopropyl-[(2R)-morpholine-2-carbonyl]amino]ethyl]-6-methylpyrazolo[5,4-b]pyridin-1-yl]propyl]carbamate

SPH3127 (DRI 18) is a novel, highly effective, and orally active direct renin inhibitor (recombinant human-renin IC50=0·4 nM, human plasma renin activity IC50=0·45 nM)· SPH3127 has antihypertensive effects and can be used in the research of hypertension

ChemicalCAS1399849-02-5MW444.53FormulaC22H32N6O4
CAS number
1399849-02-5
Molecular weight
444.53
Formula
C22H32N6O4
Solubility
DMSO ： 100 mg/mL (224·96 mM; Need ultrasonic)
InChIKey
GRTDDIZIUSADLD-CRAIPNDOSA-N
Catalogue number
GC69938
Brand
GLPBIO
Computed properties PubChem CID 117877477 · XLogP 0.8 · TPSA 111 Ų · H-bond donors 2
XLogP
0.8
TPSA
111 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
9
Heavy atoms
32

SMILES CC1=NC2=C(C=C1)C(=NN2CCCNC(=O)OC)[C@@H](C)N(C3CC3)C(=O)[C@H]4CNCCO4

Computed descriptors from PubChem (CID 117877477), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.