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Chemical structure of Skp2 inhibitor 1

GC69911

Skp2 inhibitor 1

Also known as 2-chloro-N-[1-(5,6-diphenylpyrazin-2-yl)piperidin-4-yl]acetamide

Skp2 inhibitor 1 (compound 14i) is a Skp2 inhibitor that disrupts the Skp2-Cks1 interaction, with an IC50 of 2·8 μM· Skp2 inhibitor 1 also exhibits anti-cancer activity

ChemicalCAS2760612-63-1MW406.91FormulaC23H23ClN4O
CAS number
2760612-63-1
Molecular weight
406.91
Formula
C23H23ClN4O
Solubility
DMSO : 50 mg/mL (122·88 mM; Need ultrasonic)
InChIKey
MKWLNXUIWPRODH-UHFFFAOYSA-N
Catalogue number
GC69911
Brand
GLPBIO
Computed properties PubChem CID 162718203 · XLogP 4.1 · TPSA 58.1 Ų · H-bond donors 1
XLogP
4.1
TPSA
58.1 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
5
Heavy atoms
29

SMILES C1CN(CCC1NC(=O)CCl)C2=CN=C(C(=N2)C3=CC=CC=C3)C4=CC=CC=C4

Computed descriptors from PubChem (CID 162718203), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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