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Chemical structure of SIRT6 activator 12q

GC69899

SIRT6 activator 12q

Also known as N-benzhydryl-2-(1-benzofuran-2-yl)quinoline-4-carboxamide

SIRT6 activator 12q is an effective, selective, and orally active SIRT6 activator with IC50 values of 171·20, >200, >200, >200, and 0·58 μM for SIRT1, SIRT2, SIRT3, SIRT5 and SIRT6 respectively· It inhibits cell growth and migration and induces apoptosis (cell death) and G2 phase cell cycle arrest· Additionally, it exhibits anti-cancer activity

ChemicalCAS2601734-99-8MW454.52FormulaC31H22N2O2
CAS number
2601734-99-8
Molecular weight
454.52
Formula
C31H22N2O2
Solubility
DMSO ： 25 mg/mL (55·00 mM; ultrasonic and warming and heat to 70°C)
InChIKey
JNULQPRWYHVXHT-UHFFFAOYSA-N
Catalogue number
GC69899
Brand
GLPBIO
Computed properties PubChem CID 156013743 · XLogP 6.8 · TPSA 55.1 Ų · H-bond donors 1
XLogP
6.8
TPSA
55.1 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
5
Heavy atoms
35

SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)NC(=O)C3=CC(=NC4=CC=CC=C43)C5=CC6=CC=CC=C6O5

Computed descriptors from PubChem (CID 156013743), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.