Loading...
Chemical structure of SB-435495

GC69862

SB-435495

Also known as N-[2-(diethylamino)ethyl]-2-[2-[(4-fluorophenyl)methylsulfanyl]-5-[(1-methylpyrazol-4-yl)methyl]-4-oxopyrimidin-1-yl]-N-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]acetamide

SB-435495 is an effective, selective, reversible, non-covalent and orally active inhibitor of Lp-PLA2 with an IC50 of 0·06 nM

ChemicalCAS304694-39-1MW720.82FormulaC38H40F4N6O2S
CAS number
304694-39-1
Molecular weight
720.82
Formula
C38H40F4N6O2S
Solubility
DMSO ： 100 mg/mL (138·73 mM; Need ultrasonic)
InChIKey
VGIQUSQBXZXBGW-UHFFFAOYSA-N
Catalogue number
GC69862
Brand
GLPBIO
Computed properties PubChem CID 10417440 · XLogP 6.5 · TPSA 99.3 Ų · H-bond donors 0
XLogP
6.5
TPSA
99.3 Ų
H-bond donors
0
H-bond acceptors
9
Rotatable bonds
15
Heavy atoms
51

SMILES CCN(CC)CCN(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(F)(F)F)C(=O)CN3C=C(C(=O)N=C3SCC4=CC=C(C=C4)F)CC5=CN(N=C5)C

Computed descriptors from PubChem (CID 10417440), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.