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Chemical structure of RLX-33

GC69821

RLX-33

Also known as N-[4-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]phenyl]-1-(furan-2-ylmethyl)-5-oxopyrrolidine-3-carboxamide

RLX-33 is an effective and selective relaxin family peptide 3 (RXFP3) antagonist with blood-brain barrier permeability· It also blocks the phosphorylation of ERK1/2 induced by relaxin 3, with IC50 values for RXFP3, ERK1, and ERK2 phosphorylation being 2·36 μM, 7·82 μM, and 13·86 μM respectively· RLX-33 can block the increase in food intake induced by the RXFP3 selective agonist R3/I5 in rats· RLX-33 can be used for research on metabolic syndrome

ChemicalCAS2784577-71-3MW462.89FormulaC24H19ClN4O4
CAS number
2784577-71-3
Molecular weight
462.89
Formula
C24H19ClN4O4
Solubility
DMSO ： 125 mg/mL (270·04 mM; Need ultrasonic)
InChIKey
LTOAWFRZXVPHAJ-UHFFFAOYSA-N
Catalogue number
GC69821
Brand
GLPBIO
Computed properties PubChem CID 164886639 · XLogP 3 · TPSA 101 Ų · H-bond donors 1
XLogP
3
TPSA
101 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
33

SMILES C1C(CN(C1=O)CC2=CC=CO2)C(=O)NC3=CC=C(C=C3)C4=NC(=NO4)C5=CC=C(C=C5)Cl

Computed descriptors from PubChem (CID 164886639), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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