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Chemical structure of RL648_81

GC69820

RL648_81

Also known as ethyl N-[2-amino-3-fluoro-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]carbamate

RL648_81 is a specific activator of the KQT-like subfamily 2/3 (KCNQ2/3) with an EC50 of 190 nM· RL648_81 effectively shifts the V1/2 of KCNQ2/3 channels to more hyperpolarized potentials, but has no effect on KCNQ4 or KCNQ5· RL648_81 has potential for research in neurological disorders associated with neuronal hyperexcitability

ChemicalCAS1919050-87-5MW371.33FormulaC17H17F4N3O2
CAS number
1919050-87-5
Molecular weight
371.33
Formula
C17H17F4N3O2
Solubility
DMSO ： 100 mg/mL (269·30 mM; Need ultrasonic)
InChIKey
MVSMZQRRMPUGHI-UHFFFAOYSA-N
Catalogue number
GC69820
Brand
GLPBIO
Computed properties PubChem CID 124203920 · XLogP 3.7 · TPSA 76.4 Ų · H-bond donors 3
XLogP
3.7
TPSA
76.4 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
26

SMILES CCOC(=O)NC1=C(C(=C(C=C1)NCC2=CC=C(C=C2)C(F)(F)F)F)N

Computed descriptors from PubChem (CID 124203920), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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