Loading...
Chemical structure of (Rac)-SHIN2

GC69797

(Rac)-SHIN2

Also known as 6-amino-4-[3-(hydroxymethyl)-5-(5-hydroxypent-1-ynyl)phenyl]-3-methyl-4-propan-2-yl-2H-pyrano[2,3-c]pyrazole-5-carbonitrile

(Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor with a 1,4-dihydropyran[2,3-c]pyrazole structure· It is involved in folate or one-carbon metabolism pathways and prevents viral infections· SHMT1 and SHMT2 are cytosolic and/or mitochondrial isoforms of serine hydroxymethyltransferase respectively

ChemicalCAS2204289-53-0MW406.48FormulaC23H26N4O3
CAS number
2204289-53-0
Molecular weight
406.48
Formula
C23H26N4O3
Solubility
DMSO ： 110 mg/mL (270·62 mM; Need ultrasonic)
InChIKey
IWUCUJZMKDHLOF-UHFFFAOYSA-N
Catalogue number
GC69797
Brand
GLPBIO
Computed properties PubChem CID 134335035 · XLogP 3.1 · TPSA 128 Ų · H-bond donors 4
XLogP
3.1
TPSA
128 Ų
H-bond donors
4
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
30

SMILES CC1=C2C(=NN1)OC(=C(C2(C3=CC(=CC(=C3)C#CCCCO)CO)C(C)C)C#N)N

Computed descriptors from PubChem (CID 134335035), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.