GC69792
R 59-022 hydrochloride
Also known as 6-[2-[4-[(4-fluorophenyl)-phenylmethylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one;hydrochloride
R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC50: 2·8 μM)· R 59-022 hydrochloride inhibits OAG phosphorylation to OAPA· It is also a 5-HT receptor antagonist that can activate protein kinase C (PKC)· R 59-022 enhances the production of thromboxane in platelets induced by thrombin and inhibits phosphatidic acid production in neutrophils
ChemicalCAS93076-98-3MW496.04FormulaC27H27ClFN3OS
- CAS number
- 93076-98-3
- Molecular weight
- 496.04
- Formula
- C27H27ClFN3OS
- Solubility
- DMSO ： 25 mg/mL (50·40 mM; Need ultrasonic)
- InChIKey
- APNKGVNEUKASGR-UHFFFAOYSA-N
- Catalogue number
- GC69792
- Brand
- GLPBIO
Computed properties PubChem CID 23326062 · TPSA 61.2 Ų · H-bond donors 1 · H-bond acceptors 5
- TPSA
- 61.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Rotatable bonds
- 5
- Heavy atoms
- 34
SMILES CC1=C(C(=O)N2C=CSC2=N1)CCN3CCC(=C(C4=CC=CC=C4)C5=CC=C(C=C5)F)CC3.Cl
Computed descriptors from PubChem (CID 23326062), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il