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Chemical structure of PKM2 activator 2

GC69716

PKM2 activator 2

Also known as 1-(2,6-difluorophenyl)sulfonyl-4-naphthalen-2-ylsulfonylpiperazine

PKM2 activator 2 is an activator of pyruvate kinase M2 (PKM2) with anti-proliferative effects, with an AC50 of 66 nM· PKM2 activator 2 may have anti-tumor proliferation effects and alleviate the Warburg effect, as PKM2 activation can restore normal glucose metabolism in cells

ChemicalCAS1186660-06-9MW452.49FormulaC20H18F2N2O4S2
CAS number
1186660-06-9
Molecular weight
452.49
Formula
C20H18F2N2O4S2
Solubility
DMSO ： 5 mg/mL (11·05 mM; ultrasonic and warming and heat to 60°C)
InChIKey
LLOHMBFPOYWAIL-UHFFFAOYSA-N
Catalogue number
GC69716
Brand
GLPBIO
Computed properties PubChem CID 25243723 · XLogP 3.1 · TPSA 91.5 Ų · H-bond donors 0
XLogP
3.1
TPSA
91.5 Ų
H-bond donors
0
H-bond acceptors
8
Rotatable bonds
4
Heavy atoms
30

SMILES C1CN(CCN1S(=O)(=O)C2=CC3=CC=CC=C3C=C2)S(=O)(=O)C4=C(C=CC=C4F)F

Computed descriptors from PubChem (CID 25243723), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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