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Chemical structure of PCSK9-IN-10

GC69670

PCSK9-IN-10

Also known as 8-(2-methoxyethylamino)-7-[(3-methoxyphenyl)methyl]-1,3-dimethylpurine-2,6-dione

PCSK9-IN-10 is an effective, orally active PCSK9 inhibitor with an IC50 value of 6·4 µM· It increases the expression of LDLR protein and decreases the expression of PCSK9· PCSK9-IN-10 can slow down the progression of atherosclerosis· It has potential for researching hyperlipidemia

ChemicalCAS368434-98-4MW373.41FormulaC18H23N5O4
CAS number
368434-98-4
Molecular weight
373.41
Formula
C18H23N5O4
Solubility
DMSO ： 250 mg/mL (669·51 mM; Need ultrasonic)
InChIKey
YUNMPASCLGGSKE-UHFFFAOYSA-N
Catalogue number
GC69670
Brand
GLPBIO
Computed properties PubChem CID 3769828 · XLogP 1.3 · TPSA 88.9 Ų · H-bond donors 1
XLogP
1.3
TPSA
88.9 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
27

SMILES CN1C2=C(C(=O)N(C1=O)C)N(C(=N2)NCCOC)CC3=CC(=CC=C3)OC

Computed descriptors from PubChem (CID 3769828), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
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