Loading...
Chemical structure of PAMP-12 (unmodified)

GC69652

PAMP-12 (unmodified)

Also known as (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoic acid

PAMP-12 (unmodified) is an effective MRGPRX2 (MrgX2) agonist (EC50=20-50 nM)· PAMP-12 (unmodified) is an endogenous peptide that causes hypotension by inhibiting the release of catecholamines from sympathetic nerve endings and adrenal chromaffin cells

ChemicalCAS929905-12-4MW1619.91FormulaC77H118N24O15
CAS number
929905-12-4
Molecular weight
1619.91
Formula
C77H118N24O15
Solubility
H2O ： 100 mg/mL (61·73 mM; Need ultrasonic)
InChIKey
XXTXSQXRVLRJNL-DYQOJKGJSA-N
Catalogue number
GC69652
Brand
GLPBIO
Computed properties PubChem CID 168510512 · XLogP -4.4 · TPSA 680 Ų · H-bond donors 26
XLogP
-4.4
TPSA
680 Ų
H-bond donors
26
H-bond acceptors
21
Rotatable bonds
56
Heavy atoms
116

SMILES C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC5=CC=CC=C5)N

Computed descriptors from PubChem (CID 168510512), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.