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Chemical structure of p53 Activator 7

GC69648

p53 Activator 7

Also known as 2-[3-(4-dimethylphosphorylanilino)prop-1-ynyl]-N-(1-methylpiperidin-4-yl)-1-(2,2,2-trifluoroethyl)indol-4-amine

p53 Activator 7 is a p53 mutant Y220C (MDM-2/p53) activator with an EC50 of 104 nM· It can bind to p53 mutants and restore their ability to bind DNA (WO2022213975A1; Example B-1)

ChemicalCAS2849340-59-4MW516.54FormulaC27H32F3N4OP
CAS number
2849340-59-4
Molecular weight
516.54
Formula
C27H32F3N4OP
Solubility
DMSO ： 100 mg/mL (193·60 mM; Need ultrasonic)
InChIKey
TWHPNHHZQSJOEI-UHFFFAOYSA-N
Catalogue number
GC69648
Brand
GLPBIO
Computed properties PubChem CID 166176923 · XLogP 4.5 · TPSA 49.3 Ų · H-bond donors 2
XLogP
4.5
TPSA
49.3 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
36

SMILES CN1CCC(CC1)NC2=C3C=C(N(C3=CC=C2)CC(F)(F)F)C#CCNC4=CC=C(C=C4)P(=O)(C)C

Computed descriptors from PubChem (CID 166176923), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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