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Chemical structure of Nisoxetine

GC69565

Nisoxetine

Also known as 3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine

Nisoxetine is an effective and selective norepinephrine transporter (NET) inhibitor with a Kd value of 0·76 nM· It is an antidepressant agent and local anesthetic that can block voltage-gated sodium channels

ChemicalCAS53179-07-0MW271.35FormulaC17H21NO2
CAS number
53179-07-0
Molecular weight
271.35
Formula
C17H21NO2
Solubility
DMSO : 250 mg/mL (921·32 mM; Need ultrasonic)
InChIKey
ITJNARMNRKSWTA-UHFFFAOYSA-N
Catalogue number
GC69565
Brand
GLPBIO
Computed properties PubChem CID 4500 · XLogP 3.1 · TPSA 30.5 Ų · H-bond donors 1
XLogP
3.1
TPSA
30.5 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
7
Heavy atoms
20

SMILES CNCCC(C1=CC=CC=C1)OC2=CC=CC=C2OC

Computed descriptors from PubChem (CID 4500), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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