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Chemical structure of LRRK2-IN-7

GC69402

LRRK2-IN-7

Also known as (2S)-2-[1-[6-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]pyrimidin-4-yl]indazol-6-yl]spiro[2.2]pentane-2-carbonitrile

LRRK2-IN-7 is an effective, selective, CNS-penetrant LRRK2 kinase inhibitor with an IC50 of 0·9 nM· The selectivity of LRRK2-IN-7 is over 1000-fold for other kinases, ion channels and CYP enzymes

ChemicalCAS2307277-93-4MW414.5FormulaC24H26N6O
CAS number
2307277-93-4
Molecular weight
414.5
Formula
C24H26N6O
Solubility
DMSO ： 100 mg/mL (241·25 mM; Need ultrasonic)
InChIKey
JCQABEJXHUSDMF-HOYKHHGWSA-N
Catalogue number
GC69402
Brand
GLPBIO
Computed properties PubChem CID 156493868 · XLogP 3.2 · TPSA 90.9 Ų · H-bond donors 1
XLogP
3.2
TPSA
90.9 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
31

SMILES CC(C)([C@@H]1CCN(C1)C2=NC=NC(=C2)N3C4=C(C=CC(=C4)[C@@]5(CC56CC6)C#N)C=N3)O

Computed descriptors from PubChem (CID 156493868), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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