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Chemical structure of LFHP-1c

GC69371

LFHP-1c

Also known as 1-[2-[8-[[2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoyl]amino]octylcarbamoyl]phenyl]pentyl acetate

LFHP-1c is a PGAM5 inhibitor that exhibits neuroprotective activity in ischemic stroke· LFHP-1c protects the integrity of the blood-brain barrier from ischemic damage· LFHP-1c binds to endothelial cell PGAM5, inhibits PGAM5 phosphatase activity, and suppresses the interaction between PGAM5 and NRF2· LFHP-1c has protective effects both in vitro and in vivo

ChemicalCAS2102347-47-5MW873.13FormulaC55H64N6O4
CAS number
2102347-47-5
Molecular weight
873.13
Formula
C55H64N6O4
Solubility
DMSO ： 100 mg/mL (114·53 mM; Need ultrasonic)
InChIKey
OITTXMIOSJEXLY-UHFFFAOYSA-N
Catalogue number
GC69371
Brand
GLPBIO
Computed properties PubChem CID 168355614 · XLogP 11.7 · TPSA 120 Ų · H-bond donors 2
XLogP
11.7
TPSA
120 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
23
Heavy atoms
65

SMILES CCCCC(C1=CC=CC=C1C(=O)NCCCCCCCCNC(=O)C2=CC=CC=C2C3=CC=C(C=C3)CN4C5=C(C(=CC(=C5)C6=NC7=CC=CC=C7N6C)C)N=C4CCC)OC(=O)C

Computed descriptors from PubChem (CID 168355614), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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