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Chemical structure of KWCN-41

GC69345

KWCN-41

Also known as morpholin-4-yl-[4-(1H-pyrrolo[2,3-b]pyridin-2-yl)phenyl]methanone

KWCN-41 is a selective and efficient inhibitor of RIPK1 kinase with an IC50 value of 88 nM· KWCN-41 specifically inhibits necroptosis but does not inhibit apoptosis· KWCN-41 also has anti-inflammatory effects

ChemicalCAS2913223-17-1MW307.35FormulaC18H17N3O2
CAS number
2913223-17-1
Molecular weight
307.35
Formula
C18H17N3O2
Solubility
DMSO ： 100 mg/mL (325·36 mM; Need ultrasonic)
InChIKey
SBSCPNOOKRZFKO-UHFFFAOYSA-N
Catalogue number
GC69345
Brand
GLPBIO
Computed properties PubChem CID 168451054 · XLogP 2.1 · TPSA 58.2 Ų · H-bond donors 1
XLogP
2.1
TPSA
58.2 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
2
Heavy atoms
23

SMILES C1COCCN1C(=O)C2=CC=C(C=C2)C3=CC4=C(N3)N=CC=C4

Computed descriptors from PubChem (CID 168451054), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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