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Chemical structure of KNT-127

GC69337

KNT-127

Also known as (1R,14S,15R)-25-methyl-4,25-diazahexacyclo[13.7.3.01,14.03,12.05,10.017,22]pentacosa-3,5,7,9,11,17(22),18,20-octaene-14,20-diol

KNT-127 is an effective selective δ opioid receptor agonist that works effectively through systemic administration· KNT-127 has selectivity for the δ receptor (with Ki values of 21·3, 0·16, and 153 nM for opioid receptors μ, δ, and κ, respectively)· It can increase dopamine and L-glutamate release in the striatum, ventral pallidum, and anterior cingulate cortex· It also exhibits antidepressant-like effects

ChemicalCAS1256921-89-7MW372.46FormulaC24H24N2O2
CAS number
1256921-89-7
Molecular weight
372.46
Formula
C24H24N2O2
Solubility
DMSO ： 100 mg/mL (268·49 mM; ultrasonic and warming and heat to 60°C)
InChIKey
NFXFNBIPWUYEIM-WXFUMESZSA-N
Catalogue number
GC69337
Brand
GLPBIO
Computed properties PubChem CID 52942137 · XLogP 3.4 · TPSA 56.6 Ų · H-bond donors 2
XLogP
3.4
TPSA
56.6 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
0
Heavy atoms
28

SMILES CN1CC[C@]23CC4=NC5=CC=CC=C5C=C4C[C@]2([C@H]1CC6=C3C=C(C=C6)O)O

Computed descriptors from PubChem (CID 52942137), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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