Loading...
Chemical structure of JQAD1

GC69320

JQAD1

Also known as 12-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]-N-[(5R)-3-[2-[(4-fluorophenyl)methyl-[(2S)-1,1,1-trifluoropropan-2-yl]amino]-2-oxoethyl]-2,4-dioxospiro[1,3-oxazolidine-5,1'-2,3-dihydroindene]-5'-yl]dodecanamide

JQAD1 is a CRBN-dependent PROTAC that selectively targets EP300 for degradation· JQAD1 inhibits the expression of EP300 and H3K27ac modification· JQAD1 induces apoptosis in cells· JQAD1 can be used for cancer research

ChemicalCAS2417097-18-6MW932.95FormulaC48H52F4N6O9
CAS number
2417097-18-6
Molecular weight
932.95
Formula
C48H52F4N6O9
Solubility
DMSO ： 100 mg/mL (107·19 mM; Need ultrasonic)
InChIKey
TWCIGBYYSZQAAA-GWWVHQGYSA-N
Catalogue number
GC69320
Brand
GLPBIO
Computed properties PubChem CID 162615894 · XLogP 7.6 · TPSA 192 Ų · H-bond donors 3
XLogP
7.6
TPSA
192 Ų
H-bond donors
3
H-bond acceptors
14
Rotatable bonds
20
Heavy atoms
67

SMILES C[C@@H](C(F)(F)F)N(CC1=CC=C(C=C1)F)C(=O)CN2C(=O)[C@]3(CCC4=C3C=CC(=C4)NC(=O)CCCCCCCCCCCNC5=CC6=C(C=C5)C(=O)N(C6=O)C7CCC(=O)NC7=O)OC2=O

Computed descriptors from PubChem (CID 162615894), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.