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Chemical structure of JO146

GC69319

JO146

Also known as tert-butyl N-[(2S)-1-[(2S)-2-[(1-diphenoxyphosphoryl-2-methylpropyl)carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate

JO146 is a proteinase inhibitor of Chlamydia trachomatis high-temperature requirement A (CtHtrA) required for inclusion formation, with IC50 values of 21·86 and 1·15 μM against CtHtrA and human neutrophil elastase (HNE), respectively· JO146 can be used to inhibit bacterial infections

ChemicalCAS130727-21-8MW601.67FormulaC31H44N3O7P
CAS number
130727-21-8
Molecular weight
601.67
Formula
C31H44N3O7P
Solubility
DMSO ： 100 mg/mL (166·20 mM; Need ultrasonic)
InChIKey
FOEQHKOSOICMEF-QIELNMHASA-N
Catalogue number
GC69319
Brand
GLPBIO
Computed properties PubChem CID 15928334 · XLogP 6.1 · TPSA 123 Ų · H-bond donors 2
XLogP
6.1
TPSA
123 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
13
Heavy atoms
42

SMILES CC(C)[C@@H](C(=O)N1CCC[C@H]1C(=O)NC(C(C)C)P(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3)NC(=O)OC(C)(C)C

Computed descriptors from PubChem (CID 15928334), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.