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Chemical structure of JC2-11

GC69311

JC2-11

Also known as (E)-1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one

JC2-11 is an inhibitor of inflammasomes· It inhibits the NLRP3, AIM2, and non-canonical (NC) inflammasomes that contain a recruitment domain protein· JC2-11 reduces the secretion of caspase-1 (p20), cleavage of gasdermin D (GSDMD), and release of IL-1β and lactate dehydrogenase (LDH) in inflammasomes· JC2-11 inhibits the activation of inflammasomes by disrupting the production of reactive oxygen species and the activity of caspase-1

ChemicalCAS937820-89-8MW302.3FormulaC17H15FO4
CAS number
937820-89-8
Molecular weight
302.3
Formula
C17H15FO4
Solubility
DMSO ： ≥ 100 mg/mL (330·80 mM)
InChIKey
YYAIFDXWRNNHAW-ZZXKWVIFSA-N
Catalogue number
GC69311
Brand
GLPBIO
Computed properties PubChem CID 24895134 · XLogP 3.4 · TPSA 55.8 Ų · H-bond donors 1
XLogP
3.4
TPSA
55.8 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
22

SMILES COC1=C(C=C(C=C1)C(=O)/C=C/C2=CC(=C(C=C2)O)OC)F

Computed descriptors from PubChem (CID 24895134), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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