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Chemical structure of INI-43

GC69279

INI-43

Also known as 3-(1H-benzimidazol-2-yl)-1-[3-(dimethylamino)propyl]pyrrolo[3,2-b]quinoxalin-2-amine

INI-43 is an inhibitor of Kpnβ1, which interferes with the nuclear localization of Kpnβ1 and known Kpnβ1 cargo proteins, NFAT, NFκB, AP-1 and NFY

ChemicalCAS881046-01-1MW385.46FormulaC22H23N7
CAS number
881046-01-1
Molecular weight
385.46
Formula
C22H23N7
Solubility
DMSO : 10 mg/mL (25·94 mM; ultrasonic and warming and heat to 60°C)
InChIKey
LWPQQQAILAUWTI-UHFFFAOYSA-N
Catalogue number
GC69279
Brand
GLPBIO
Computed properties PubChem CID 4910351 · XLogP 2.9 · TPSA 88.7 Ų · H-bond donors 2
XLogP
2.9
TPSA
88.7 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
29

SMILES CN(C)CCCN1C(=C(C2=NC3=CC=CC=C3N=C21)C4=NC5=CC=CC=C5N4)N

Computed descriptors from PubChem (CID 4910351), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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