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Chemical structure of Tuspetinib

GC69233

Tuspetinib

Also known as 5-chloro-N-[3-cyclopropyl-5-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)pyrimidin-2-amine

Tuspetinib (HM43239) is a selective FLT3 inhibitor with oral activity, with IC50 values of 1·1 nM (wild-type FLT3), 1·8 nM (FLT3 ITD mutation), and 1·0 nM (FLT3 D835Y mutation)· As a reversible type I inhibitor, Tuspetinib directly inhibits the kinase activity of FLT3 and regulates p-STAT5, p-ERK SYK, JAK1/2, and TAK1· Tuspetinib inhibits the proliferation of leukemia cells and induces apoptosis

ChemicalCAS2294874-49-8MW501.07FormulaC29H33ClN6
CAS number
2294874-49-8
Molecular weight
501.07
Formula
C29H33ClN6
Solubility
DMSO ： 125 mg/mL (249·47 mM; Need ultrasonic)
InChIKey
FZLSDZZNPXXBBB-KDURUIRLSA-N
Catalogue number
GC69233
Brand
GLPBIO
Computed properties PubChem CID 135390910 · XLogP 5.8 · TPSA 68.9 Ų · H-bond donors 3
XLogP
5.8
TPSA
68.9 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
36

SMILES C[C@@H]1CN(C[C@@H](N1)C)CC2=CC(=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=C4C=CC(=C5)C)Cl)C6CC6

Computed descriptors from PubChem (CID 135390910), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.